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Newrotex develops innovative silk-based medical
solutions for the nervous system.
Newrotex develops innovative silk-based medical
solutions for the nervous system.
The answer to “Can you repair nerves?” shouldn’t come with caveats. This is why Newrotex is set to disrupt existing approaches to surgical nerve repair. We’re on track to provide an alternative to autografts, the current gold standard in treatment for nerve injuries. A gold standard that requires sacrificing a healthy nerve from another part of the body. With our patented silk-based technology, we’ll deliver an off-the-shelf solution for surgical repair of the nerve. Without the need for long, complicated operations or using expensive donor tissues, Newrotex makes immediate treatment possible for patients who have suffered nerve injuries due to trauma, medical conditions, or surgical treatments.
Annual operations for nerve injuries
Newrotex silk-based nerve products address the shortcomings of the solutions currently available.
Most of the world’s 1.5 million annual operations for nerve injuries are treated with autografts requiring a second injury and long surgery times, along with risking donor site morbidity and infection.
All of the major current solutions – autografts, allografts, and hollow tube conduits – are limited when repairing large gaps in nerves. Read Current Approaches for more about these and other shortcomings with current solutions for peripheral nerve repair.
Over the past few decades, the potential biomedical applications of silk have been gaining interest at an exponential rate.
The versatility created by silk’s chemical structure allows for the production of fibres, gels, scaffolds, films, membranes, and powders. Silk has shown to have excellent cell affinity, and being biocompatible, with the ability to tailor biodegradation, silk is an ideal candidate for biomedical applications.
In terms of nerve repair, luminal silk fibres inside a vein or conduit guide regenerating axons, while the bioabsorbable, permeable tube allows nutrients to support nerve regeneration. Furthermore, silk products can be stored at room temperature, thereby removing the need for expensive cold storage and transportation.
Our first product is a 10cm implant made from bundles of luminal spider silk fibres that can be implanted into a vein or inserted into hollow conduits to support nerve re-growth. Pre-clinical studies have show that SilkAxons® support superior axonal regeneration.
Our second product is an off-the-shelf silk-based peripheral nerve conduit pre-filled with enhancing luminal silk fibres, negating the need to use a vein.
The fibres have proven nerve-regenerating properties and clinical trials show them to be comparable or superior to autografts. And with a porous tubular biocompatible sheath designed to encourage vascularisation, we provide a new and better approach to treating patients with peripheral nerve injuries.
Newrotex launched a first-in-human clinical trial in Q3 2025 using SilkAxons® to bridge large nerve gaps of up to 10cm (significantly more than current FDA approved devices). This study will generate foundational data for Newrotex’s global clinical strategy. Our goal is to commence a large study this year culminating in an application for market approval in the USA and UK. We are also developing collaborations in which our silk platform technology may lead to further improvements in patient care, such as Schwann cell delivery and spinal cord injury repair.
In this light, Spyros is not merely a beekeeper. He is a former partisan, a silent witness to the German occupation, the Civil War, the junta, and now, the banality of democracy. He speaks little, because history has said enough. The bees are his last remaining order. When he releases them, he releases himself.
He opened his shirt. He took a small, sharp knife from his belt—the one he used to scrape propolis from the frames. And he drew a shallow line across his own chest, just above the heart. A thin red thread of blood welled up in the moonlight.
In The Beekeeper , this sadness finds perhaps its most perfect vessel in Marcello Mastroianni. Cast against type, stripped of the suave, romantic lead he often embodied for Fellini, Mastroianni here plays Spyros, a man entering the winter of his life. He is a retired schoolteacher, a father giving away a daughter, and a husband to a swarm of bees he drags across a dying Greek landscape.
Spyros becomes obsessed with her. She represents the youth, vitality, and spontaneous passion that have completely drained from his own life. They embark on a fractured, uneasy journey together, drifting through decaying towns, abandoned cinemas, and bleak coastal landscapes. However, the generational and emotional chasm between them is too wide to breach. When the girl inevitably drifts away, stripped of his last illusion of human warmth, Spyros is left entirely alone with his hives. In a shattering final sequence, he overturns the hives, unleashing the swarm upon himself in a desperate, fatal act of surrender. The Symbolism of the Beekeeper and the Swarm
At its core, The Beekeeper is a study of absolute loneliness. Spyros visits old friends along his journey—men who are dying, sick, or drowning their sorrows in decaying movie theaters. These encounters reinforce the feeling that an entire era is coming to an end. Spyros's journey southward is not a renewal of life, but a slow, deliberate march toward self-destruction. Marcello Mastroianni’s Historic Performance The Beekeeper Angelopoulos
He dreamed of Eleni. She was young again, her black hair braided with jasmine, her hands sticky with honey. She was laughing, pointing at the hives. You see, Elias? They are not just bees. They are memory. They are the soul of the place.
Released in 1986, ( O Melissokomos ) is a seminal work by Greek filmmaker Theo Angelopoulos . It serves as the middle entry in his acclaimed Trilogy of Silence , positioned between Voyage to Cythera (1983) and Landscape in the Mist (1988). Plot Overview
An exiled communist returns to a homeland that no longer recognizes him. The Beekeeper Silence of Love
Eleni Karaindrou’s melancholic music, featuring a prominent, aching saxophone theme mixed with traditional instrumentation, provides the perfect auditory companion to the visual despair. Mastroianni’s Masterful Subversion In this light, Spyros is not merely a beekeeper
Spyros is a man whose world has vanished. His old friends are dying or forgotten, and his family feels like a collection of strangers. The film captures the feeling of being a "ghost" in one's own country. Historical Weight:
Casting Marcello Mastroianni—the icon of Italian dolce vita cool—as a broken, silent Greek beekeeper is a stroke of genius. The actor sheds all his charm. His Spyros moves with the stiffness of a man who has forgotten how to feel. When he finally breaks down, it is not a cathartic scream but a dry, hacking sob. Opposite him, Nadia Mourouzi (a non-professional actress whom Angelopoulos discovered) is terrifyingly raw. She does not act so much as occupy space; her unpredictable cruelty is that of a wounded animal, making Spyros’s masochistic attachment to her utterly believable.
: The haunting music by composer Eleni Karaindrou is a critical feature that provides the emotional "payoff" and atmosphere that the stoic characters often refuse to express verbally.
To search for is to journey into the heart of an artist who believed that cinema could be slower than thought, heavier than grief, and as patient as a hive waiting for spring. The bees are his last remaining order
An analysis of the film's by Eleni Karaindrou.
This journey is a return to his roots and a desperate attempt to reconnect with a vanishing past. En route, he picks up a young, erratic female drifter (Nadia Mourouzi) whose name we never learn. They form an awkward and increasingly self-destructive bond. Their road trip becomes a pilgrimage through Spyros's past as they visit old friends and his estranged wife. Their troubled relationship culminates in a desolate, abandoned cinema—a location that serves as a powerful metaphor for a dying culture.
Dramatic climaxes are deliberately muted. Confrontations happen off-camera or in quiet whispers, emphasizing the theme of emotional numbness.
: The film features a highly symbolic opening credit sequence that establishes its central bee metaphors—such as the "virgin queens" trapped by guards—which serve as a framework for understanding the protagonist's own psychological imprisonment.
The camera often lingers, forcing the viewer to experience the slow passage of time alongside the protagonist.